Study of recurrent spontaneous abortion and activated protein C-resistance
Abstract：Objective To understand the occurrence of activated protein C-resistance(APCR)in patients with recurrent spontaneous abortion(RSA)and investigate the occuring mechanism of APCR inducing the mini-thrombosis of placental vessels which results in RSA.Methods APC-KPTT assay,ELISA and PTT-LA methods were used respectively to detect APCR,anticardiolipin antibodies(ACA)and lupus anticoagulant(LA) in 32 patients with RSA and 20 normal controls(NC).Results There were 17 positive of APA(antiphospholipid antibodies) in patients.The incidence (53.1%) was significantly higher than that of NC group(0/20)(P＜0.005),the incidence of LA in RSA(28.1%) was higher than that in NC group(0/20)(P＜0.01),but there was no significant difference of ACA between the two groups (P＞0.05).The incidence of APCR in RSA(37.5%) was significantly higher than that of NC group(5.0%)(P＜0.001),but the APC-SR was lower than NC group(P＜0.05).Relativity analysis indicated that the incidence of APCR in LA-positive group(66.7%) was obviously higher than that in LA-negative(26.1%)(P＜0.05),but there was no significant difference between the ACA-positive and the ACA-negative(P＞0.05).Conclusion There is a little bit higher incidence of APCR in patients with RSA and it is related to LA,which suggests that APCR seems to be one of the main reasons to induce the thrombosis in placental vessels which results in RSA.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 285-287 )