Effect of oral high dose mifepristone on apoptosis and telomerase activity of endometrial carcinoma.
Abstract：Objective To investigate the effect of oral high dose mifepristone on apoptosis and telomerase activity of endometrial carcinoma and to explore the possible mechanism associated with this effect. Methods Twelve untreated patients with endometrial carcinoma received high dose mifepristone ( 100mg/day for 5days) treatment. On the sixth day,these patients underwent operations. Immunohistochemistry assay( LSAB method) was applied to determine Fas and FasL expression changes of endometrial tissues between pre-and post-administration of high dose mifepristone. Using semiquantitative telomere repeat amplification protocol(TRAP)method, telomerase activity was measured. Results Mter administration of high dose mifepristone, expression of Fas was more intense than that of pre-treatment sections ( P＜0.01). There were no remarkable changes of FasL immunostaining and telomerase activity( P＞0. 05 ) after high dose mifepristone treatment. Conclusion High dose mffepristone can promote apoptosis of endometrial carcinoma but has no effect on telomerase activity.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 225-227 )