Insulin and glucose levels in maternal serum, umbilical artery and venous serum: comparision between normal pregnan cy and intrauterine growth retardation
Abstract：Objective To determine levels of insulin and glucose in maternal serum(MS), umbilical artery serum(UAS)and
umbilical venous serum(UVS) in women with normal- term pregnancy and intrauterine growth retardation(IUGR). Methods
107 cases with normal gestational weeks(induction of labors or spontaneous deliveries)and 32 cases complicated with IUGR
were studied. Levels of insulin were measured with sensitive radioimmunoassay and that of glucose were measured by the glucose
oxidase- peroxidase method. Results Level of insulin of maternal serum was not significantly different before 28 gestational
weeks, and peaked on 28th gestational week, then it decreased with gestational weeks and peaked again at last term. Insulin level
in UAS increased gradually to its peak value at 36th gestational week and then decreased and increased apain,while that in UVS
demonstrated no regular changes. Levels of glucose in MS, UAS, UVS were not significantly different. Level of insulin and glu
cose of MS in IUGR had no significant change, but they were significantly different in IUGR of UAS and UVS( P ＜ 0.01 ).
Conclusion A decrease of insulin and glucose in UAS and UVS of IUGR was found, which suggested that insulin and glucose
played an important role in the growth and development of fetus.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 45-46 )