Targeted temperature management in pediatric neurocritical care
ZHOU Li-bing
BAI Zhen-jiang
Abstract：Targeted Temperature Management(TTM)is a crucial neuroprotective strategy in pediatric neurocritical care,yet several key problems remain unresolved in its clinical application.Due to immature neurological development,high metabolic rates,and weak thermoregulation,children are more susceptible to secondary brain injury mediated by mitochondrial dysfunction,oxidative stress,and neuroinflammatory responses following acute neurological insults.TTM may exert neuroprotective effects by reducing cerebral metabolism,suppressing inflammation,and inhibiting apoptosis.However,the optimal implementation protocol(e.g.,target temperature,duration,rewarming rate)and the risk-benefit ratio in specific populations require further validation through large-scale clinical studies and long-term follow-up.
Keywords：targeted temperature managementchildneuroprotection
Publication Date：2025-10-06
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：6( 813-818 )