Plasmapheresis in the treatment of toxic epidermal necrolysis in children:report on 3 cases
YE Feng
LIANG Yu-feng
TAO Jian-ping
WU Zhi-yuan
Abstract：From January 2022 to December 2023,the Pediatric Intensive Care Unit(PICU)of the Women and Children's Medical Center Affiliated to Guangzhou Medical University admitted 3 children with toxic epidermal necrolysis(TEN),aged 4,8 and 13 respectively.The areas of skin lesion were 50％,70％and 90％respectively,and the involved sites were the eyes,nasal cavity,oral cavity,external genitalia,urethral orifice and perianal mucosa respectively.The SCORTEN score and the in-hospital mortality rate assessment were 2/12％,2/12％,and 3/32％,respectively.After ineffective treatment with glucocorticoids and intravenous immunoglobulin(IVIG),2 to 5 sessions(1.5 to 2.0 times the plasma volume each time)of plasma exchange(PE)treatment were given respectively,with an interval of 48 hours between each two sessions.After treatment,the skin lesions of all three cases improved significantly,and the inflammatory factors decreased significantly,while no ocular complications such as visual field defects occurred.The article holds that PE may be an effective treatment method for children with TEN.
Keywords：childtoxic epidermal necrolysisplasma exchangeinflammatory factor
Publication Date：2025-09-06
Online Publishing Date：2025-11-05(First online date of this platform, not the publication date of the document)
Pages：5( 779-783 )