Research progress on risk factors and comorbidity mechanisms of pediatric allergic airway diseases and tic disorders
SHEN Wen-xin
YU Si-jia
SHAN Li-shen
Abstract：Pediatric allergic airway diseases and tic disorders,as chronic conditions,are increasingly prevalent,which not only affect the quality of life but also impose substantial economic and social burdens.Clinical studies have revealed a significant correlation between tic disorders and allergic diseases,both of which are associated with immune system imbalances.The symptoms involve various parts or organs,and the pathogenesis is complex,severely impacting the quality of life.Potential factors influencing the development of these diseases include maternal depression and anxiety,maternal allergy history,maternal tobacco exposure history,sleep disorders,and environmental pollution.Furthermore,gut microbiome dysbiosis and T-cell immune imbalance may be potential factors underlying the comorbidity of the two conditions.Exploring and understanding these shared risk factors and comorbidity mechanisms increases the cognition about these two diseases,which is of great significance for the prevention and treatment of allergic airway diseases and tic disorders.
Keywords：allergic airway diseasestic disordersrisk factorsgut microbiotacellular immunity
Publication Date：2025-09-06
Online Publishing Date：2025-11-05(First online date of this platform, not the publication date of the document)
Pages：6( 773-778 )