Diagnosis and treatment of childhood-onset systemic lupus erythematosus
ZHANG Yu-di
SHEN Tian
WU Xiao-chuan
Abstract：Childhood-onset systemic lupus erythematosus(cSLE)is a chronic autoimmune disease characterized by acuter onset,severer clinical manifestations,and poorer prognosis than those of adult-onset SLE.Early diagnosis and standardized treatment are crucial for improving outcomes.Currently,the diagnosis primarily relies on the 2012 SLICC and 2019 EULAR/ACR criteria,which were developed based on adult populations.Although these criteria perform well in the diagnosis of cSLE,they still have limitations in clinical practice.In the treatment a"treat-to-target"goal is emphasized and individualized treatment is conducted.Conventional therapy primarily consists of glucocorticoids combined with immunosuppressants,while the use of biologics can help reduce steroid use,lower disease activity,and decrease disease recurrences.The 2024 ACR guidelines recommend multitarget combination therapy for proliferative lupus nephritis,which shows promising results in adult patients.However,its actual efficacy and long-term safety in pediatric populations still require further validation.
Keywords：systemic lupus erythematosustargeted therapyindividualized treatment
Publication Date：2025-09-06
Online Publishing Date：2025-11-05(First online date of this platform, not the publication date of the document)
Pages：6( 746-751 )