Diagnosis and management of chronic nonbacterial osteomyelitis in children
MA Le
FAN Zhi-dan
HUANG Na
YU Hai-guo
Abstract：Chronic nonbacterial osteomyelitis is a rare autoinf-lammatory bone disease characterized by recurrent nonbacterial osteomyelitis.The lesions mainly affect long bones,spine,and anterior chest wall,presenting as nocturnal bone pain caused by single or multiple bone marrow inflammations.The disease progresses chronically and insidiously,with significant heterogeneity in clinical manifestations.Delayed treatment can lead to irreversible bone destruction.This article reviews and summarizes the disease from aspects such as pathogenesis,clinical manifestations,diagnostic criteria,differential diagnosis,and treatment strategies,aiming to improve pediatricians' understanding of the disease and provide a theoretical basis for standardized diagnosis and treatment.
Keywords：chronic nonbacterial osteomyelitischronic recurrent multifocal osteomyelitisautoinflammatory bone disease
Publication Date：2025-09-06
Online Publishing Date：2025-11-05(First online date of this platform, not the publication date of the document)
Pages：7( 734-740 )