Research status in the pathogenesis of very-early-onset inflammatory bowel disease
XIAO Xiong
ZHOU Juan
ZHAO Hong-mei
XIA Yu
YOU Jie-yu
Abstract：Inflammatory bowel disease(IBD)is a group of nonspecific chronic gastrointestinal inflammatory diseases with unknown etiology,including Crohn's disease(CD),ulcerative colitis(UC)and undifferentiated IBD(IBD-U),among which IBD with onset less than 6 years old is called very-early-onset inflammatory bowel disease(VEO-1BD).It is a special subgroup in children with IBD.Different from IBD in adults or older children,VEO-IBD has the characteristics of early onset,severe symptoms,and accompanied by perianal lesions.The children can have extensive gastrointestinal symptoms and severe growth retardation,and the effect of traditional drug treatment is poor.With the development and wide application of high-throughput gene sequencing technology,more than 70 related pathogenic genes have been discovered.This article systematically expounds the pathogenesis of VEO-IBD,focusing on the pathogenic mechanism of gene mutations,the microbiota-host relationship,and the guiding significance for precision medicine practice.
Keywords：very-early-onset inflammatory bowel diseasepathogenesisgeneimmunity
Publication Date：2025-07-06
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：8( 593-600 )