Expert consensus on clinical application of macrolide antibiotics in children(2025 edition)
Pediatric Pharmaceutical Committee of Chinese Pharmaceutical Association
Cooperative Group of Rational Drug Use,Respiratory Group,Pediatrics Society of Chinese Medical Association
Respiratory Group of Professional Committee of Child Allergology
Editorial Committee of Chinese Journal of Practical Pediatrics
LIU Han-min
LU Quan
LI Zhi-ping
Abstract：Macrolide antibiotics have been developed since a long time ago with various types,and are widly used in clinical practice,which rank No.1 in the use of antibiotics in domestic pediatric outpatient departments.Macrolide antibiotics have a strong antibacterial effect on a variety of pathogens,however the resistance rate of pediatric isolates of Streptococcus,Staphylococcus and Mycoplasma pneumoniae to macrolide antibiotics is also very prominent.The 14-membered and 15-membered ring macrolides have some anti-inflammatory and immunomodulatory effects in addition to broad-spectrum antibacterial activity.Given that children's dynamic physiological development differs from adults',it is urgent to have a specific guidance document for the clinical application of macrolides in children.The consensus gives a systematic summary of drug characteristics,pharmacokinetics and pharmacodynamics of macrolide antibiotics;meanwhile,the consensus gives comprehensive recommendations on the use of macrolide antibiotics in children with infectious diseases,adverse reactions and non-antibacterial effects,so as to standardize their rational clinical use.
Keywords：antimicrobial drugsmacrolidesconsensuschild
Publication Date：2025-06-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 441-451 )