Research progress on the etiology of Kawasaki disease
GU Xin-yu
GONG Fang-qi
Abstract：Kawasaki disease(KD)is a systemic vasculitis that is more common in children under 5 years old.It can cause coronary artery lesions,and is the main cause of acquired heart disease in children.Early high-dose intravenous immunoglobulin(IVIG)combined with aspirin is currently the first-line treatment.Although Kawasaki disease has a history of more than 50 years since it was first reported and the incidence has been rising years after years,its specific etiology and pathogenesis still remain unclear,which is widely concerned by pediatricians in clinical practice.In order to understand KD better and provide ideas for its further diagnosis and treatment,this article discusses the current research status of KD etiology from the perspectives of infection,genetics and immunity.
Keywords：Kawasaki diseaseetiologyinfectious factorsgenetic susceptibilityimmune mechanism
Publication Date：2025-05-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 425-432 )