Update on the pathogenesis of IgA vasculitis in children
JIN Yan-yan
LIN Qian
HE Xue
MAO Jian-hua
FU Hai-dong
Abstract：IgA vasculitis(IgAV),is one of the most common forms of small blood vessel inflammation in children.While the precise pathogenesis of IgAV remains to be fully understood,it is widely accepted that the condition involves a complex interaction of genetics,immune system,and environmental factors.Typically,IgAV resolves on its own;however,in some cases,it can progress to nephritis or even end-stage renal disease.Researches indicate that there are significant variations in the incidence of IgAV across different populations,with genetic predisposition playing a crucial role in the development of the disease.Furthermore,studies suggest that the formation and deposition of galactose-deficient(Gd-)IgA1 immune complexes may be the primary cause of tissue damage,although the exact mechanism is still a matter of controversy.T cell dysfunction has a significant effect on the pathogenesis of IgAV.In this review,we will study the roles of genetic factors,immune dysfunction,infections,and endothelial cell injury in the pathogenesis of IgA vasculitis.
Keywords：childIgA vasculitisgalactose-deficient IgA1HLA geneimmune function
Publication Date：2025-05-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 418-424 )