MOG antibody-associated disease with prolonged fever as the main presentation:report on six cases
DING Xiu-fang
JIN Rui-feng
LI Juan
Abstract：A retrospective analysis was performed on the medical data of 6 children with positive anti-myelin oligodendrocyte glycoprotein(MOG)antibody and prolonged fever,who attended the Children's Hospital Affiliated to Shandong University from January 2021 to September 2021,in order to explore the clinical characteristics of MOG antibody-related diseases with prolonged fever as the main manifestation.The medical data included clinical manifestations,physical examinations,and auxiliary examinations.The results showed that all 6 cases had prolonged fever as the main clinical manifestation;only 1 case had a positive Babinski sign upon physical examination.In all 6 cases,the white blood cell(WBC)counts in blood routine were elevated,ranging from 19.8 to 34.0 × 109/L,with a neutrophil percentage of 77.4％to 89.9％;the erythrocyte sedimentation rate was between 61 and 105 mm/h,and the C-reactive protein was between 21.6 and 57.3 mg/L.WBC counts in the cerebrospinal fluid ranged from(15～180)×106/L.Inflammatory changes were observed in 3 cases in the brain magnetic resonance imaging(MRI),with 1 case showing inflammatory signal changes in the thalamus and cerebellum on day 35 of the disease course.Two cases had an MOG antibody titer of 1∶100,3 had an MOG antibody titer of 1∶32,and 1 had an MOG antibody titer of 1∶320.From this,it can be concluded that MOG antibody-related diseases can cause prolonged fever.
Keywords：feverunknown origindemyelinationanti-myelin oligodendrocyte glycoprotein antibody-associated disordersencephalitis
Publication Date：2025-04-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 348-352 )