Chinese expert consensus on the clinical application of arsenic trioxide in pediatric solid tumors
Pediatric Oncology Committee of Chinese Anti-Cancer Association
Pediatric Oncology Committee of Guangdong Anti-Cancer Association
Editorial Board of Chinese Journal of Practical Pediatrics
LI Yang
LUO Xue-qun
Abstract：Arsenic trioxide(ATO),a traditional Chinese medicine with a longstanding history,is renowned for its efficacy in the treatment of acute promyelocytic leukemia(APL).Recently,more and more studies have demonstrated that ATO exhibits anti-tumor effects across a variety of malignancies,and it also showed some effects in the clinical treatment of pediatric tumors,which deserves further study.The lack of established guidelines and consensus regarding its clinical application in pediatric solid tumors has prompted the Specialty Committee of Pediatric Oncology of the Chinese Anti-Cancer Association and the Specialty Committee of Pediatric Oncology of Guangdong Anti-Cancer Association to organize domestic experts to make literature review and analysis and summary regarding the history of ATO,its anti-tumor mechanisms,its clinical application,and its pharmacokinetics.A full discussion was carried out concerning the indications,administration methods and the management of adverse reactions associated with ATO use in pediatric solid tumors,and reasonable suggestions were put forward based on evidence-based medical evidence and clinical experience,aiming to provide clinicians with evidence for the rational use of ATO in order to better improve the prognosis of pediatric patients with tumors and offer valuable references for pharmaceutical management departments.
Keywords：arsenic trioxidetumorpediatricclinical applicationconsensus
Publication Date：2025-04-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：13( 271-283 )