Analysis of differences in fractional exhaled nitric oxide levels among children with different allergic types of asthma
ZHU Si-yu
ZHAO Ran
LI Fei-die
TANG Yong-yu
DONG Xiao-yan
Abstract：Objective To explore the clinical value of fractional exhaled nitric oxide in monitoring airway inflammation in children with different allergic types of asthma.Methods This was a retrospective study.The clinical data ofasthma children aged from 6 to 18 years were collected,who visited Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University from March 2020 to March 2023.The patients were divided into different groups according to allergen results:inhalant allergy group(inhalation group),food allergy group(food group),mixed allergy group(mixed group),and allergen-negative group(control group).The differences in fractional expiratory nitric oxide levels among the groups were compared,and stratification analysis was made concerning asthma control,recent infection and history of rhinitis.Results The study included 487 children with asthma with allergen information,328 boys and 159 girls,including 455 allergen-positive children,among whom 238 children were in inhalationgroup,36 children in food group,181 in mixed group and 32 children in control group.FeNO50 and FeNO200 in inhalation group and mixed group were significantly higher than those in food group and control group(P＜0.001).CaNO was not different among the groups(P＞0.05).Under the conditions such as good control of asthma,no infection,and combination with rhinitis,FeNO50 and FeNO200 were significantly higher in the inhalation group and the mixed group than in the food group and the control group(P＜0.05).CaNO was higher in the inhalation group and the mixed group than in the food group among the children with good asthma control and combination with rhinitis(P＜0.05).Conclusion FeNO50 and FeNO200 are significantly higher in the inhalation group and the mixed group than in the food group and the control group.CaNO is not different among the groups.FeNO50,FeNO200 and CaNO are significantly increased in children with inhalant and mixed allergic asthma who are well-controlled and with a history of rhinitis,and the airway inflammatory response is more obvious.Fractional exhaled nitric oxide better reflects and monitors the severity of airway inflammation in children with inhalant allergy asthma and mixed allergy asthma,which can be a guide for adjusting diagnostic and therapeutic strategies.
Keywords：allergic asthmaallergenchildfractional exhaled nitric oxideairway inflammation
Publication Date：2025-02-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)