Clinical value of urinary NAG and serum Cys-C in early renal damage of simple obesity in children
WANG Xiao-yan
HUA Min
WANG Feng-yun
XIE Rong-rong
CHEN Lin-Qi
CHEN Xiu-li
CHEN Ting
SUN Hui
ZHANG Dan-dan
WANG Li-li
WU Hai-ying
Abstract：Objective To investigate the clinical value of urine N-acetyl-β-D-glucosaminidase(uNAG)and serum cystatin-C(Cys-C)in the assessment of early renal damage in children with simple obesity.Methods A total of 302 children with simple obesity were selected,who were diagnosed in the Department of Endocrinology,Genetics and Metabolism of Children's Hospital of Soochow University from October 2021 to January 2024,and 53 children of similar age in the same period were selected as the normal control group.The clinical data of the two groups were collected,including basic data,blood and urine test results,compare the differences in clinical data of different stages of obesity and normal control group.Analyze the correlation between serum Cys-C,urine NAG,and kidney function.Compare simple obesity group based on their urnie albumin creatine raio(UACR),dividing them into an albuminuria group and a normal albuminuria group.Examine the differences in general clinical data and laboratory parameters between these two subgroups.Multivariate Logistic regression analysis was used to identify the predictors of renal damage.Results There were statistically significant differences in total cholesterol(TC),triglyceride(TG)and triglyceride-glucose index(TyG)between the obese albuminuria group and the obese no-albuminuria group(P＜0.05),and there were significant differences in β2-microglobulin(mALB),uNAG and UACR(P＜0.05).In the obese albuminuria group,uNAG was moderately positively correlated with mALB and UACR,and moderately negatively correlated with β2M.uNAG was an independent influencing factor for early renal damage in children with simple obesity.The area under the ROC curve was the largest in the combined detection of uNAG and serum Cys-C,and the specificity and sensitivity were relatively high.Conclusion The children with simple obesity may have early kidney damage.uNAG is an independent influencing factor for early renal damage in children with simple obesity.The combination of uNAG,uNAG and serum Cys-C has certain value in the evaluation of early renal damage in children with simple obesity.
Keywords：simple obesity in childrenurine n-acetyl-β-D-glucosaminidaseobesity-related renal damage
Publication Date：2025-02-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)