Advances in genetics of pediatric hypertrophic cardiomyopathy
LIU Jia-ling
LIU Fang
Abstract：Hypertrophic cardiomyopathy(HCM)is one of the most common inherited cardiomyopathies in children,with pathological features including cardiomyocyte enlargement,cardiomyocyte disturbances and myocardial fibrosis,and the typical clinical feature is the presence of left ventricular hypertrophy that cannot be explained by abnormal loading.Although great progresses have been made in the comprehensive medical and surgical treatment of HCM,the disease progression cannot be reversed,and the prognosis of HCM is still poor.Therefore,with the continuous development of molecular biology,the genetic diagnosis and treatment of HCM is expected to become a new diagnosis and treatment scheme.This article reviews the current progress in the genetic research of HCM in children.
Keywords：hypertrophic cardiomyopathygenetic diagnosisgene therapy
Publication Date：2024-12-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 954-960 )