Expert consensus on immune assessment and clinical management of BCG vaccine disease
Inborn Errors of Immunity Alliance of National Children's Medical and Clinical Research Center(IEI.CHN)
HUANG Wen-yan
JIN Yan-liang
LI Ke-li
LI Xiao-zhong
LING Yun
LU Mei-ping
MAO Hua-wei
SUN Bi-jun
SUN Jin-qiao
TANG Xue-mei
WANG Xiao-chuan
Abstract：Bacillus calmette-guerin(BCG)disease is an abnormal reaction that may occur after inoculation with the BCG vaccine,especially in immunodeficient children.Inborn Errors of Immunity Alliance of National Children's Medical and Clinical Research Center(IEI.CHN)has developed an expert consensus to standardize the diagnosis and treatment of BCG disease.The consensus states that BCG disease can be divided into local infection,regional infection,distant infection and disseminated infection.The diagnosis is based on BCG vaccination history,clinical presentation,and etiological or pathological evidence.Assessment of immune function is critical in children with distant and disseminated infections.Therapeutically,prophylactic anti-tuberculosis therapy is recommended for immunodeficient children susceptible to BCG.For IEI patients with BCG disease,long-term anti-tuberculosis therapy is required.Some types of IEI require radical treatment by hematopoietic stem cell transplantation.The consensus also highlights the importance of immunotherapy,especially for Mendelian genetic mycobacterium susceptibility diseases with reduced interferon-gamma production.
Keywords：BCGinborn errors of immunitychronic granulomatous diseasesevere combined immunodeficiency diseaseMendelian susceptibility to mycobacterial diseasediagnosistreatment
Publication Date：2024-12-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 894-900 )