Assessment of islet cell function in children and adolescents with type 1 diabetes
YOU Feng-yan
SUN Yan
XU Hai
Abstract：Type 1 diabetes is mainly caused by T cell-mediated islet cell-specific immune damage.The characteristics include decreased C-peptide and insulin,positive diabetes-related antibodies,more diabetic ketoacidosis,and dependence on insulin therapy.In clinical practice it is difficult to classify type 1 and type 2 diabetes in some children and adolescents due to atypical clinical features.The assessment of islet β cell function provides an important evidence for the classification.This article summarizes the evaluation methods of islet β cell function,including oral glucose tolerance test,serum C-peptide and insulin production index,aiming to improve the ability to evaluate residual islet function in patients with type 1 diabetes,increase the level in identifying diabetes children,and provide better guidance to the treatment and follow-up of children with type 1 diabetes.
Keywords：type 1 diabeteschildren and adolescentsislet cell functionglucose tolerance testβ-cell homeostasis assessment model
Publication Date：2024-11-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 873-876 )