Treatment for children with septic shock based on pathophysiology
YING Jia-yun
LU Guo-ping
Abstract：Sepsis is a dysregulated host response to infection leading to life-threatening organ dysfunction with a complex pathophysiology that involves major mechanisms including immune imbalance,microcirculatory disorders,and mitochondrial dysfunction.Septic shock,a combination of sepsis with cardiovascular dysfunction,is one of the etiologic factors contributing to high mortality in critically ill children.This article summarizes the key points of treatment of septic shock in children based on pathophysiology,including infection control,immunomodulation,and improvement of microcirculation and mitochondrial function,which will help clinicians understand the treatment of septic shock in children.
Keywords：septic shockinfectionimmunemicrocirculationmitochondria
Publication Date：2024-09-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 669-673 )