Research progress of inflammasome-associated autoinflammatory diseases
WU Jun-feng
TANG Xue-mei
Abstract：The inflammasome is a macromolecular multi-protein complex in cells,and its activation can regulate the activation of cysteine aspartic protease-1(CASP1),promote the activation and secretion of IL-1β and IL-18,and cause inflammation in the body.In recent years,researchers have conducted extensive studies on the molecular composition and activation mechanisms of different inflammasomes,and a variety of inflammasome molecules have been characterized,among which the self-activating mutations of four inflamm-asome can lead to single-gene autoinflammatory diseases in humans.This review focuses on the research progress of the pathogenesis,clinical manifestations and treatment of NLRP1,CARD8,NLRP3,NLRC4 and Pyrin inflammasome-related autoinflammatory diseases.
Keywords：autoinflammatory diseasesinflammasomeinfla-mmasomapathies
Publication Date：2024-06-06
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 432-438 )