Correlation analysis between different levels of proteinuria and renal pathological changes in children with IgA nephropathy

LUAN Xiao-fei; JIANG Hong

doi:10.19538/j.ek2018020611

Abstract：Objective To investigate the correlation between different levels of proteinuria and renal pathological lesion in children with primary IgA nephropathy,in order to provide references for the treatment and condition assessment.Methods A total of 32 IgAN patients with a renal biopsy from the Pediatric Department of the First Affiliated Hospital of China Medical University from August 2005 to July 2015 were chosen.According to the level of 24 h urinary protein (UP),the 32 cases were separated into 3 groups:mild group(UP ＜ 0.5 g,n =17),moderate group(0.5-2.0 g,n =9) and severe group(UP ＞ 2 g,n =6).Their clinical and pathological data were studied retrospectively.Results The proportion of patients with mild,moderate and severe proteinuria were 53.1％,28.1％ and 18.8％ respectively.Proteinuria was positively correlated with glomerular integral and tubular interstitial integral(P ＜ 0.05).The majority of pathological changes of IgAN were grade Ⅱ and grade Ⅲ,each with 14 cases (43.8％).With the increasing level of albuminuria,the degree of pathological damage increased (P ＜ 0.05).Crescentic lesions were found in 13 cases (40.6％),and with the increasing degree of the proteinuria,the incidence of crescent lesions had an increasing tendency (P ＜ 0.05).Conclusion There is correlation between proteinuria and renal pathological changes in children with IgA nephropathy.The level of proteinuria can reflect the pathological damage of glomerular and renal tubule to a certain extent.Children with mild proteinuria,who have IgA nephropathy,also have the potential to progress to ESRD.They need to be treated actively to reduce urinary protein and delay the progression of the disease.