Mitochondria-associated nephropathy
ZHANG Ai-hua
CHE Ruo-chen
Abstract：Mitochondrial dysfunction plays a critical role in the pathogenesis of kidney diseases,which can be divided into inherited mitochondrial cytopathy and acquired mitochondrial dysfunction.Mitochondrial cytopathy involves mtDNA point mutations,fragment deletion and rearrangements,mtDNA depletions and nuclear genes mutations.Acquired mitochondrial dysfunction refers to oxidative phosphorylation disorder and decrease of mtDNA copy number due to various causes.All the above-mentioned might induce podocytes injury,tubular dysfunction,interstitial nephropathy,cystic renal diseases as well as carcinoma.At present,the therapy for mitochondrial cytopathy is still deficient.Genetic therapy and mitochondria-targeted protective agents may offer potential treatments for renal diseases.
Keywords：mitochondrial cytopathymitochondrial dysfunctionkidney
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 117-121 )