Research progress in congenital nephrosis and renal interstitial fibrosis
WANG Xiu-li
WU Yu-bin
Abstract：Congenital abnormalies of the kidney and urinary tract (CAKUT) are the main cause of chronic kidney disease (CKD)in childhood.Congenital hydronephrosis is a common type of CAKUT and is usually detected by prenatal renal ultrasonography.Severe congenital nephrosis can cause renal injury and end-stage renal disease (ESRD).The etiology of congenital nephrosis is complicated and involves the abnormal expression of multiple genes.Studies on human tissue specimens and animal models show that oxidative stress,chronic inflammation and apoptosis result in renal tubular atrophy and renal fibrosis.With advanced biological techniques such as proteomics,new biological markers are emerging for early disease detection and the choice of the optimal treatment and monitoring.
Keywords：congenital nephrosisrenal fibrosischronic renal diseaseureteropelvic junction obstruction
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 105-109 )