Positron emission computed tomography findings of neuropsychiatric systemic lupus erythematosus in children
Abstract：Objective To analyse the positron emission computed tomography(PET/CT) findings of neuropsychiatric systemic lupus erythematosus (NPSLE) in children.Methods Patients diagnosed with NPSLE treated at Department of Pediatrics,Peking Union Medical College Hospital from April 2012 to February 2014 were recruited.PET/CT using F-18-labelled fluorodeoxyglucose (18F-FDG) was performed in patients with NPSLE,and the results were analyzed.Results A total of 19 patients received 18F-FDG PET/CT and 13 of them were females.Age was from 7to14 years and median age was 11.3 years.The most common neuropsychiatric manifestation was headache (8/19),followed by seizure (7/19),cognition dysfunction (2/19),psychiatric disease (1/19) and ataxia (1/19).All patients under MRI examination,and only 4 of them were abnormal.19F-FDG PET/CT revealed significant glucose hypometabolism in all patients.The temporal lobe (17/19) was the most susceptible brain regions,followed by the parietal lobe (16/19),occipital lobe (14/19) and frontallobe (10/19).In contrast,glucose hypermetabolism was detected in basal ganglia (8 patients) and thalamus (3 patients).Conclusion PET reveals significant glucose hypometabolism with or without local hypermetabolism in patients with NPSLE.
Keywords：neuropsychiatric systemic lupus erythematosuspositron emission computed tomographysystemic lupus erythematosus
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 51-54 )