Correlation analysis between serum vitamin D levels and disease activity as well as bone mineral density in children with juvenile idiopathic arthritis

doi:10.19538/j.ek2018010613

Abstract：Objective To assessed serum level of 25 (OH) D3 in children with juvenile idiopathic arthritis,in order to find the association between the vitamin D and disease activity as well as bone mineral density.Methods We evaluated 110 patients (58 females and 52 males,mean age being 9.04±3.37 years) that fulfilled the 2011 ILAR criteria for juvenile idiopathic arthritis.Patients underwent laboratory tests of serum25 (OH) D3,plasma parathyroidhormone and dualenergyx-ray absorptiometry examination.JIA patients were categorized by ACR standard of disease status in 2011,and the disease activity was measured by using JADAS-27.We analyzed the relationship between serum 25 (OH)D3 level and other indexes.Results The mean serum 25 (OH)D3 level of 110 JIA patients was (49.8± 15.3) μmol/L.Vitamin D deficiency was detected in 59 patients (53.6％) and insufficiency in 43 patients (39.1％).Patients with active disease had significantly reduced serum 25 (OH)D3 levels compared to patients with inactive disease (t =5.162,P ＜ 0.001),but there was no significant association between serum 25 (OH)D3 level and JADAS-27 (r =-0.72,P ＞ 0.05).JIA patients with vitamin D deficiency showed a significantly lower bone mineral density than those with normal 25 (OH)D3 level (t =3.791,P ＜ 0.05).Patients using glucocorticoid showed significantly lower 25 (OH) D3 level than those who never used glucocorticoid(t =2.823,P＜0.01).Conclusion JIA patients have reduced serum 25(OH)D3,particularly those with active disease or/and using glucocorticoid.JIA patients with vitamin D deficiency showed a significantly lower bone mineral density.