Inflammatory bowel disease and immunodeficiency in children
SUN Li
LI Yi-fan
Abstract：Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal inflammatory disease that can present at any age.There has been a dramatic increase in the incidence of pediatric IBD over the past 50 years.Very-early-on-set IBD(VEO-IBD) is defined as onset of IBD within the first 6 years of life,which constitutes 4％ to 10％ of pediatric IBD cases.It is generally accepted that many patients with VEO-IBD are associated with a greater degree of genetic susceptibility,and many of these diseases are classified as primary immunodeficiencies (PID).Monogenic defects have been found to alter intestinal immune homeostasis via several mechanisms,including dysfunction of innate immune system,dysfunction of adaptive immunity or disruption of the epithelial barrier.Due to the differences in the prognosis and medical management,an early diagnosis of an IBD combined with immunodeficiency should be made via genetic analysis.A proper treatment can be selected to achieve the effect of early intervention,thus improving the prognosis.
Keywords：very-early-onset inflammatory bowel diseaseimmunodeficiencygenetic analysistreatment
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 37-41 )