Clinical outcome of seventy-three cases of pediatric acute T lymphoblastic leukemia and analysis of prognosis factors
Abstract：Objective To analyze the clinical characteristics and prognosis of pediatric acute T lymphoblastic leukemia.Methods Clinical characteristics of 73 children with acute T lymphoblastic leukemia and T-cell lymphoblastic lymphoma involving the bone marrow treated in Peking University People's Hospital from March 2003 to March 2014 were retrospectively analysed,and the prognosis factors were analyzed.Results Of the 73 patients,25 children relapsed and 3 died from complications during chemotherapy or transplantation.Their 5-year CRF was (37.89±6.02)％ and 5-year EFS was (58.74±6.01)％.The 5-year EFS decreased significantly when the initial onset age was more than 13.The 5-year CRF increased significantly when the initial onset size of spleen was bigger than 9 cm under the costal margin or the IgH rearrangement was positive.The 5-year CRF decreased significantly and 5-year EFS increased significantly when average peak methotrexate (MTX) blood concentration was more than 40 μmol/L during high-dose MTX chemotherapy.Conclusion The treatment result of children with T-ALL is unsatisfactory.Initial onset age ≥13 and huge spleen indicate poor prognosis.Positive IgH rearrangement may be associated with high risk of recurrence.T-ALL patients can benefit from high-dose MTX therapy.
Keywords：childacute T lymphoblastic leukemiarelapseprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 856-860 )