Value of serum intestinal fatty acid binding protein and serum amyloid A in the diagnosis of severe necrotizing enterocolitis in the newborn
Abstract：Objective To investigate the value of serum intestinal fatty acid binding protein(I-FABP) and serum amyloid A (SAA) in the diagnosis of necrotizing enterocolitis (NEC)in the newborn.Methods Fifty-six preterm infants with a confirmed diagnosis of NEC from October 2014 to October 2015 were recruited as case group (stage Ⅰ:26 cases;stage Ⅱ/Ⅲ:30 cases).Thirty children diagnosed with non-digestive diseases in the same period were recruited as the control group.Serum levels of Ⅰ-FABP and SAA were determined by enzyme-linked immunosorbent assay.The diagnostic value of Ⅰ-FABP and SAA for severe NEC was assessed using the receiver operating characteristic (ROC)curve.Results Stage Ⅱ/Ⅲ cases in the case group had significantly higher serum Ⅰ-FABP levels and SAA levels than the control group and Stage Ⅰ cases (P ＜ 0.05).The area under the ROC curve for serum Ⅰ-FABP was 0.80 (95％CI:0.69-0.92),with the optimal cut-off point of 21.8 μg/L.Under this cut-off point,the sensitivity and specificity were 70.0％and 81.0％,respectively.The area under the ROC curve for SAA was 0.76 (95％CI:0.63-0.89),with the optimal cut-off point of 1657.8 μg/L.Under this cut-off point,the sensitivity and specificity were 67.0％ and 80.0％,respectively.Conclusion In newborn infants with NEC,serum Ⅰ-FABP and SAA l can be used as biomarkers for the diagnosis of severe NEC.
Keywords：intestinal fatty acidbinding proteinserum amyloid Anewborn infantnecrotizing enterocolitis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 838-841 )