Research advance of celiac disease in children

SUN Mei; YE Xiao-lin

doi:10.19538/j.ek2017100608

Abstract：Coeliac disease is an immune-mediated systematic disorder induced by ingestion of gluten.The typical clinical manifestations are gastrointestinal signs including diarrhea,bloating,weight loss and abdominal pain.It can also be manifested as extra-intestinal symptoms,such as iron-deficiency anemia,growth retardation,delayed puberty and recurrent mouth ulcers.Some children are considered to be at high risk of developing coeliac disease,such as those with a family history,who carry a susceptibility gene or have other autoimmune diseases.If the child is suspected with coeliac disease,serological screening with anti-tissue transglutaminase titers should be carried out first,and then the diagnosis may be confirmed by small bowel biopsy with a normal diet.For the treatment of celiac disease lifelong adherence to a gluten-free diet is needed,which can effectively relieve the clinical symptoms and prevent long-term complications.Therefore,clinicians should beware of the different clinical manifestations to ensure early diagnosis and timely application of gluten-free diet therapy.