Association between polymorphisms of IL12RB1 and IL12RB2 genes and the susceptibility to tuberculosis in Chinese Han children
Abstract：Objective To explore the association between polymorphisms of IL12RB1 and IL12RB2 genes and the susceptibility to tuberculosis (TB) in Chinese Han children.Methods A case-control study was performed in 362 Chinese Han pediatric TB patients admitted to Beijing Children's Hospital between February 2005 and October 2011,and 400 healthy controls.MassARRAY was used for genotyping in 16 single nucleotide polymorphisms (SNPs) of IL12RB1 and IL12RB2 genes.Logistic regression was used to analyze differences of allele and genotype distributions of SNP polymorphisms between the two groups,and the multifactor dimensionality reduction (MDR) method was used for analyzing the association between the interactions of SNPs and susceptibility to TB.Results No statistical difference was found in the allele,genotype and haplotype distributions of all SNPs in IL12RB1 and IL12RB2 genes between the two groups (P ＞ 0.0036).The MDR method results indicated that there was no association found between the interactions of all SNPs and susceptibility to TB (P ＞ 0.0036).Conclusion No association is found between polymorphisms of IL12RB1 and IL12RB2 genes and susceptibility to TB in Chinese Han children.
Keywords：tuberculosisIL12RB1IL12RB2single nucleotide polymorphisminteractionChina
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 693-697 )