Clinical characteristics and outcome of adolescent patients with acute lymphoblastic leukemia

doi:10.19538/j.ek2017090610

Abstract：Objective To summarize the clinical characteristics and outcome of adolescent patients with acute lymphoblastic leukemia (ALL) treated with Chinese Children's Leukemia Group (CCLG)-2008 protocol over a 5-year period from 2008 to 2013.Methods Clinical features,immunophenotypes,cytogenetic abnormalities and prognosis of adolescent patients aged 10 to 18 were compared with younger patients under 10 years old.Results During 2008-2012,723 patients with ALL were enrolled in our study.About 14.11％ of them were 10-to 18-year old patients.Compared to younger ones,adolescent patients demonstrated a higher incidence of T-cell lineage phenotype (14.71％ vs 5.8％),t (9;22) (8.82％ vs.4.99％),t (1;19) (8.82％ vs.5.15％),and significantly lower frequency of t (12;21)(21.74％ vs.8.82％).In intermediate group,the 5-year overall survival rate(OS) and event-free survival rate(EFS) of adolescent patients was compatible with paediatric patients,(92.88％ vs.90.86％) and (77.09％ vs.82.9％),respectively.However,the EFS of adolescent patients with high-risk ALL was worse than paediatric patients (42.78％ vs.54.12％).Conclusion Despite the increased incidence of adverse prognostic factors,the survival rate of adolescent patients has been improved when treated with paediatric ALL protocol.However,the poor prognosis of adolescent patients in the high-risk group remains to be the current challenge.