Progress in the diagnosis and treatment of hypophosphatemic vitamin D resistant rickets
ZHANG Cai
LUO Xiao-ping
Abstract：Hypophosphatemic Vitamin D resistant rickets is a group of metabolic bone diseases characterized by increase renal excretion of phosphate and hypophosphatemia.Regulation of phosphate homeostasis includes a complicated feedback network,in which parathyroid hormone (PTH),fibroblast growth factor-23 (FGF23) and 1,25-(OH)D3 are key regulatory factors.With the understanding of phosphate regulation and the pathogenesis of this disease,progresses have been made in the diagnosis and treatment in hypophosphatemic rickets recently.In this review,based on the mechanisms of phosphate regulation,we explain the pathogenesis and clinical manifestations of hypophosphatemic rickets,and summarize up-to-date diagnostic and therapeutic approaches.
Keywords：hypophosphatemic vitamin D resistant rickets125-(OH)2D3PTHFGF23X-linked-hypophosphatemic rickets
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 669-673 )