Risk factors for neonatal necrotizing enterocolitis: An analysis of 76 cases

HOU A-na; LI Xue; FU Jian-hua

doi:10.19538/j.ek20170806013

Abstract：Objective To analyze the influence of perinatal period factors,feeding strategies,probiotics usage,complications and mechanical ventilation before the onset of the disease on neonatal necrotizing enterocolitis (NEC),in order to explore the risk factors for NEC.Methods Totally 76 infants with NEC were classified as the case group,who were hospitalized in the First Neonatal Department of Shengjing Hospital of China Medical University from January 2011 to January 2016;80 infants without NEC who were admitted at the same time were randomly selected as the control group.A retrospective analysis was performed on the clinical data of these patients,including general conditions of newborns,perinatal period factors,feeding strategies,probiotics usage,complications and mechanical ventilation before the development of NEC.Single and multiple factor analysis was performed on 19 items using the SPSS analysis software.Results Single factor analysis revealed that the incidence of asphyxia,sepsis,hypoglycemia and mechanical ventilation was higher,while the incidence of oral probiotics usage was lower in the case group than the control group,with statistically significant difference (P ＜ 0.05).According to the logistic multivariate regression analysis,sepsis(OR =6.531),hypoglycemia (OR =2.785) and mechanical ventilation (OR =3.448) were risk factors of NEC,while oral probiotics usage was protective factor of NEC (OR =0.417).Conclusion Sepsis,hypoglycemia and mechanical ventilation are risk factors of NEC,and oral probiotics usage is protective factor of NEC.We should pay attention to the prevention and intervention of NEC by reasonably analyzing these factors,in order to improve the prognosis of these children.