A study on the efficacy of bifidobacterium BB-12 in treatment of children with acute diarrhea

doi:10.19538/j.ek2017070614

Abstract：Objective To evaluate the efficacy and safety of bifidobacterium BB-12 in treatment of children with acute diarrhea.Methods In this single-blind study,120 infant patients with diarrhea treated in the First Hospital of Jilin University from Dec 2015 to Aug 2016 were randomized into three groups:(1)treatment group:treated with Bifidobacterium BB-12;(2)positive control group:treated with live combined Bacillus subtilis and Enteroeoecus faeeium;(3)placebo group:treated with maltodextrin.There were 40 patients in each group,and all received montmorillonite and fluid replacement.Clinical data of each group were analyzed and compared.Results The significant efficiency and efficiency of the treatment group was 37.50％ and 52.50％,the positive control group was 42.50％ and 42.50％,the placebo group was 17.50％ and 52.50％.The treatment group had no significant difference with the positive control group,but significantly higher than that of the placebo group;At the 4th day,the frequency of patients' defecation of the treatment group was (3.10± 1.41)/d,the positive control group was (3.05 ± 1.63)/d,the placebo group was (3.93 ± 1.91)/d,at the 7th day,the frequency of patients' defecation of the treatment group was (1.45 ± 0.64)/d,the positive control group was (1.43±0.90)/d,the placebo group was (1.95-± 1.30)/d,the treatment group was similar to the positive control group,and was significantly less than the placebo group.The average duration of diarrhea of each group was (4.20± 1.32) d,(4.40± 1.37) d,(5.18± 1.57) d.Conclusion Bifidobacterium BB-12 is safe and effective in the treatment of infantile diarrhea.