Determination of the level of fecal short-chain fatty acids of bacterial associated metabolites in children with Henoch-Schonlein purpura and its clinical value

doi:10.19538/j.ek2017070612

Abstract：Objective To determine the level of fecal short-chain fatty acids (SCFA) of bacterial associated metabolites in children with Henoch-Schonlein purpura(HSP) and study its clinical value.Methods From June 2014 to January 2015,twenty-seven children with HSP and twenty-eight healthy children were enrollded in this study.The fecal samples were collected respectively in the acute phase and in the remission phase.SCFA were e×tracted from children's feces,and quantitatively analyzed by gas chromatography (GC).Results The content of acetic acid in control subjects (6.04±2.15) × 10-5 was significantly higher than that in active stage of patients with HSP [(3.90±3.08) × 1 0-5,P ＜ 0.05],while there were no significant differences between control subjects and remission stage of patients [(4.73±3.95)× 10-5,P ＞ 0.05].The level of butyric acid was significantly higher in the controls [4.53 (2.68,5.47)] × 10-5 than that in the active stage of patients with HSP [1.48 (0.14,3.78) × 10-5,P ＜ 0.0 i 7] and the remission stage of patients [0.93 (0.31,1.75) × 10-5,P＜0.017].Compared with the active stage of patients,the level of acetic acid and butyric acid in the remission stage of patients was not significantly different.No significant differences were found in the results of propionic acid,or isobutyric acid or isovaleric acid (all P ＞ 0.017).Conclusion The levels of acetic acid and butyric acid in feces are significantly decreased in patients with HSP at active stage.The content of acetic acid increases in remission period,but doesn't fully return to normal level.However the fecal butyric acid content is much lower in remission period.