Clinical and pathological analysis of 753 children with renal diseases

doi:10.19538/j.ek2017070611

Abstract：Objective To explore and conclude the pathological categories and clinical data of childhood renal diseases and understand the importance of renal biopsy in childhood renal diseases.Methods Totally 753 patients who underwent percutaneous renal biopsy from 1995 to 2015 were selected as study subjects,and their clinical and pathological information was analyzed retrospectively.Results Among 753 patients who underwent percutaneous renal biopsy,428 cases (56.84％) had primary glomerular disease,306 cases (40.64％) had secondary glomerular disease,17 cases (2.26％) had heritage glomerular disease,and 2 cases (0.27％) had renal tubular interstitial disease.The most common clinical diagnosis were primary nephritic syndrome.The most common clinical diagnosis and pathological category in primary glomerulary disease were primary nephritic syndrome and IgA nephropathy respectively,and in secondary glomerulary disease they were purpura nephritis and mesangial proliferative glomerulonephritis respectively.Thin basement membrane disease and Alport's syndrome are the most common pathological category of the heritage glomerular disease.The 8 repeated renal biopsies showed pathological and clinical progression.Conclusion The primary glomerulary disease is the main type of childhood glomerulary diseases.The most common clinical diagnosis and pathological category are primary nephrotic syndrome and mesangial proliferative glomerulonephritis respectively.The repeated renal biopsy is beneficial to control the transformation of pathological types and adjust new treatments timely.