Colchicine therapy for Chinese children with familial Mediterranean fever: An analysis of 12 cases
Abstract：Objective To assess the efficiency of colchicine therapy in the treatment of Chinese pediatric patients with familial Mediterranean fever(FMF).Methods In the prospective trial,pediatric patients with proven FMF,either by Tel Hashomer criteria or by MEFV gene testing,received colchicine treatment.The following indexes and results were recorded,including the clinical manifestations and signs,CRP,ESR,MEFV sequencing results of pathogenic genes,and the dosage,effective rate and follow-up of colchicine treatment.Results Twelve children(10 diagnosed by Tel Hashomer criteria vs.2 by MEFV sequencing) were enrolled in the study,with the median age at diagnosis/initiation of colchicine of 8 (1 ～ 10) years.They received colchicine treatment at the dose of 0.01 ～ 0.025 mg/(kg· d).Among them 11 completed the study,while 1 (8.3％) had anaphylaxis and quit.During a median follow-up of 11 (8～ 38) months,the response rate was 100％.Conclusion Colchicine is effective in Chinese children patients with FMF,which should be given as earlier as possible to prevent the consequent damage caused by chronic inflammation.
Keywords：autoinflammatory diseasesfamilial Mediterranean feverMEFVcolchicinechild
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 522-525 )