Advances in allogeneic-hematopoietic stem cell transplantation for primary immunodeficiency diseases
YU Jie
HU Ming-feng
LUO Ming-jing
Abstract：Allogeneic-hematopoietic stem cell transplantation (HSCT) is the most important or even the only radical cure for some primary immunodeficiency diseases.The long-term survival is 90％ or even higher with HLA matched sibling donor transplantation.In total,the overall survival for the patients with severe combined immunodeficiency disease,Wiskott-A1drich sydrome and chronic granulomatous disease is 70％,80％ and 90％,respectively.Proper conditioning regimen promotes the success of transplantation,while severe graft versus host disease and reactivation of cytomegalovirus in patients negetively affect the overall survival and life quality after transplantation.This review summerized the rencent advances in allogeneic-HSCT for primary immunodeficiency patients with respect to alternative donor transplantation,conditiong regimen consideration,prevention and treatment of graft versus host disease and reactivation of cytomegalovirus.
Keywords：hematopoietic stem cell transplantationprimary immunodeficiency diseasegraft versus host diseasecytomegalovirus
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 496-502 )