Change of FeNO and serum SIgG4, IL-4 and INF-γ levels using SILT in children with mites allergic asthma
Abstract：Objective To investigate the change of FeNO and serum SIgG4,IL-4 and INF-γ levels before and after SLIT in children with mites allergic asthma.Methods All 118 cases with mites allergic asthma were randomly divided into two groups:the control group (59 cases) was treated with ladder type inhalation,and the treatment group (59 cases) was administered dust mite drops on the basis of conventional treatment.FeNO and serum SIgG4,IL-4 and INF-γ levels were measured before and after treatment.Results After treatment,the levels of FeNO and serum IL-4 were decreased in treatment group than before treatment(P ＜ 0.05),the levels of serum SIgG4,INF-γand the ratio of INF-γ/IL-4 were increased (P ＜ 0.05).Compared with the control group,the levels of FeNO and serum IL-4 were decreased in treatment group after treatment (P ＜ 0.05),the levels of serum SIgG4 and INF-γ and the ratio of INF-γ/IL-4 were increased (P ＜ 0.05).After treatment,the scores of allergic asthma symptom were decreased significantly in treatment group than before treatment (P ＜ 0.05).Conclusion SLIT can decrease airway inflamation and correct immune imbalance in children with mites allergic asthma.
Keywords：dermatophagoidies farinea dropsallergic asthmaimmunotherapychild
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 463-466 )