Immunodynamics and immunosuppression in sepsis

LI Ning; ZENG Qi-yi

doi:10.19538/j.ek2017060603

Abstract：Sepsis is the leading cause of death among critically ill patients.The long-term immunosuppression after recovery of an acute sepsis event is a major reason for the high mortality rate in long term outcomes.Understanding immunodynamics of sepsis and its immunosuppression is very important to prevent and reduce the immunosuppression,decrease mortality.Hyperinflammation is in the early stage of the immunodynamics of sepsis.The exorbitant release of inflammatory mediator and cytokines impairs tissue cells in inflammatory reaction,and at the same time,also causes immune cells damage and immune suppression consequently,which is the basis of sepsis immunosuppression.Middle stage of sepsis is mixed immune status.During this pcriod,inflammatory and anti-inflammatory mechanism compete with each other,while the inflammatory lesions continue and immune function is further restrained;in the later stage of sepsis,further deterioration and severer immunosuppression leads to immune dysfunction,and immunoparalysis in the end.There is no specific therapy for immunosuppression according to immunodynamics,and further researche is needed.