(KM2007L18)Study on intestinal mucosal barrier in children with Henoch-Schoniein purpura

Abstract：Objective To study the changes of intestinal mucosal barrier in children with Henoch-Schoniein purpura (HSP). Methods The plasma diamine oxidase , D-lactic acid and endotoxin were detected in 60 children with HSP and 30 normal children by the biochemistry methods. Results The level of plasma diamine oxidase , D-lactic acid and endotoxin before treatment in HSP group was higher than that in the normal control group, there being statistically significant difference (P < 0.01). The level of plasma diamine oxidase , D-lactic acid and endotoxin before treatment in HSP group with gastrointestinal symptoms were higher than that in HSP group without gastrointestinal symptoms and control group and there was also a significant difference between than(P < 0.01). Comparing the measured level of plasma diamine oxidase , D-lactic acid and endotoxin before and after treatment, with the exception of HSP group without gastrointestinal symptoms .there was no significant difference (t = 1.753, P > 0.05);however,there was significant in other groups (t = 2.556 , P < 0.01). Conclusion There is damage to intestinal mucosal barrier and its function are damaged in children with HSP , especially in HSP group with gastrointestinal symptoms. The repair of the intestinal mucosal barrier occurs during treatment.