Relationship between adipocytokines and adiposity in children and adolescents

Abstract：Objective To explore the relationship between adipooytokines and the degree of obesity in children and adolescents. Methods Based on the Beijing child and adolescent metabolic syndrome (BCAMS) study in 2004, 3511 children (1790 boys and 1721 girls) aged 6～18 were recruited. In this study, participants were categorized into three groups: 1626 cases in normal weight group(non-obese group) , 655 cases in overweight group and 1230 cases in obese group, according to the sex, age and specific body mass index(BMI) . The levels of adipocytokines were measured by sensitive, specific double - antibody sandwich enzyme - linked immunosorbent assays (ELISA) . Analysis of covariance and multiple binary logistic regression analysis were performed in statistical analysis. Results The levels of plasma insulin and serum leptin in overweight group and obese group were higher than those in non-obese group, and they increased with the increase of the degree of obesity. There were significant differences in sex.The level of serum adiponectin decreased as the degree of obesity increased. There was higher serum resistin level only in obese group than that in non-obese group.After adjustment for sex, age and pubertal development in multiple binary Logistic regression analysis , the odds ratios (OR ) and 95% confidence intervals of overweight and obesity were 4.38 (3.37 ～ 5.70) and 12.75(10.11 ～ 16.08) for predicting hyperinsulinemia, respectively, 10.42(7.46～ 14.57) and 41.53(30.23 ～ 57.07) for hyperleptinae-mia, respectively, 1.88(1.50～2.35) and 2.81(2.33～3.39) for hypoadiponectinaemia, respectively, 1.07(0.86～1.34) and 1.32(1.10～1.57) for hyperresistinaemia , respectively. Conclusion The levels of plasma insulin, serum leptin and adiponectin in children and adolescents may be intimately related to degree of obesity. The abnormal rates of their levels increase as the weight of children increases. The prevention and management of obesity in children and adoles-cents should be of great importance to the prevention of chronic diseases in manhood.