Clinical outcomes of extremely premature infants

TIAN Luan-ying

Abstract：Objective To analyze the mortality, morbidity and a variety of perinatal and neonatal factors of extremely premature infants with gestafional age of < 28 weeks. Methods The clinical charts of 219 infants with gestational age of < 28 weeks cared in NICU of St Louise Children's Hospital in USA were reviewed and the data were analyzed retrospectively with SPSS software. Results The mortality was 37.7% and NEC, grade 3 or 4 IVH and PIH were independent risk factors for death. For survivors, the mean length of hospital stay was (106.0±78.1) days; the duration of mechanical ventilation, nasal continuous positive airway pressure and oxygen administration, was (30.8±38.5)days,(10.5±11.5)days and (84.0±46.7)days, respectively. The incidences of RDS, PDA, BPD, IVH, ROP, PVL, NEC and BSI were 85.5%,62.3%,74.2%,36.5%,71.1%, 12.6%, 12.6% and 29.6%, respectively, with 55.9% infants discharging home on oxygen. Conclusion Survival without disability is possible, but the morbidities are still high in extremely premature infant with gestational age of < 28 weeks. Individualized discussions and approaches to this group of infants are suggested.