Relationship between family history and dyslipidemia in children

YAN Hui; MI Jie; LIU Ying; CHENG Hong; CHEN Jian-jun; ZHANG Xiu-zhi; DU Jun-bao

Abstract：Objective To investigate the relationship between family history and dyslipidemia in children. Methods This study was performed by research group on adult chronic diseases prevention and therapy in children.Cluster random-ized sampling in a transecting epidemiological survey of children aged 6 to 18 years in Beijing area were used; 9665 boys and 9641 girls were virtually included in the study. They were divided into four subgroups, including school boys,school girls, adolescent boys and adolescent girls. Parent history of metabolic syndrome and premature cardiovascular diseases were defined as first degree family history, grandparent or/and uncle/aunt history of metabolic syndrome and cardiovascular diseases were defined as second degree family history, while others were defined as without family histo-ry. Fasting capillary blood total cholesterol (TC) and triglyceride (TG) levels were detected. Results TC and TG lev-els of school boys and adolescent boys with first degree family history were all much higher than boys without family his-tory (4.07±0.41)mmo/L vs (4.00±0.33) mmo/L, P < 0.05; TG of adolescent girls was significantly higher than girls with-out family history (1.26±0.75) mmo/L vs (1.20±0.66) mmo/L,P < 0.05. TC and TG levels of school boys and adoles-cent boys with second degree family history were all much higher than boys without family history(P < 0.05) ; TC levels of school girls and adolescent girls with second degree family history were all much higher than girls without family histo-ry (P < 0.05). Possibility of dyslipidemia of school and adolescent boys and school girls with first degree family history was much higher than those with non-first degree family history (11.6 % vs 7.1%, 11.2 % vs 8.4%, 10.8% vs 8.0%, P < 0.05). Possibility of dyslipidemia of adoles-cent boys and girls with second degree family history were significantly higher than those without family history (10.3% vs 7.8%, 14.7% vs 11.8%, P < 0.05). Conclusion The lipid level of children differed significantly according to differ-ent background of family history. Not only first degree family history but also second degree family history ought to be considered in screening of dyslipidemia in children.