A review of clinical treatment of 12 children with severe influenza A (H1N1)

WANG Ying; BIAN Feng-zhi; DENG Kun

Abstract：Objective To investigate the clinical features and treatment of influenza A (H1N1) in children. Methods Clinical data of 12 children with severe influenza A (H1N1) were analyzed retrospectively. Results 12 patients were all fever onset, of whom, 9 were respiratory symtom onset and with sore throat, cough, expectoration and other flu-like symptoms; 1 case was with diarrhea of digestive symptom onset and 1 case was neurological symptom onset; 2 patients were with obvious asthmatic suffocation and dyspnea; 3 children were heard with coarse tales and wet rales in both lungs, and 2 cases were heard with wheezing sound. Besides, the white blood cells (WBC)count in 12 patients showed that 4 cases were with high WBC count, while 3 low; neutral category of WBC: 4 cases increased, 4 reduced; lymphocyte ratio: 4 cases were high, 2 cases low; platelet count: 1 case reduced, and 1 increased. ALT of 6 cases increased, AST of 7 cases increased, LDH of 7 cases increased, CK of 7 cases increased and CK-MB in 3 cases increased. With the patients' condition improved, WBC, liver function and myocardial enzymes returned to the normal level. Conclusion The symptoms of patients with severe influenza A (H1N1) are all respiratory tract onset and the main target organs are the lungs, often associated with bacterial and mycoplasmal infection, and with the emergence of various complications involving multiple-organ dysfunction. The conditions of children with neurological symptom onset in particular progress rapidly and they are in greater danger.