Value of biochemical markers in the diagnosis of biliary atresia and NICCD
PENG Bing-wei
XU Yi
YE Jia-wei
OU Xi
SU Yan-li
Abstract：Objective To evaluate the value of biochemical markers in the diagnosis of biliary atresia (BA) and neona-tal intrahepatic cholestasis caused by citrin deficiency (NICCD). Methods Totally 77 infants in hospital with infantile hepatitis syndrome (IHS) were enrolled from December 1, 2008 to March 31, 2009. Totally 27 patients were diagnosed as having BA and 11 with NICCD. Biochemical markers were compared between groups including alanine transaminase ALT, aspartate transaminase AST, alkaline phosphatase ALP, γ-glutamyl transpeptidase γ-GT, total bilirubin TB,direct bilirubin DB, total bile acid TBA, total cholesterol TC, to compute ALT/AST, ALP/γ-GT and glucose GLU, lac-tic acid LAC, total protein TP, albumin ALB in the NICCD group. The data were analyzed by T test and ROC curve with SPSS10.0. Results γ-GT was significantly elevated in the infants with BA when compared to non-BA group (P=0.003); cut-off point was 332.5U/L. ALP/γ-GT was significantly lower in the patients with BA, and cut-off point was 1.93. The infants with NICCD had significantly different biochemical markers including GLU, LAC, TP, ALB, ALT/ AST and γ-GT. Conclusion Biochemical markers could be considered as complementary diagnosis of BA and NICCD for differentiating infants with IHS.
Keywords：infantile hepatitis syndrome (IHS)biliary atresia (BA)neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)diagnosis
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 940-942 )