Treatment of aplastic anemia with intensive immunosuppressive agents in children
Abstract：Objective To investigate the therapeutic effects of intensiveimmunosuppressive agents on aplastic anemia in children. Methods Thirty-one cases of aplastic anemia in children from 1991～1999 in our hospital were divided into three groups according to different treatment:Group A with fundamental therapy, such as stanzolol,654-2, etc.; Group B with cyclosporin A ( CSA ) and Group C with intensive immunosuppressive agents. Results The response rate of Group A,B,C was 27.27% ,57.14% and 76. 92% respectively. It was 11.11% ,50. 00% and 75.00% in SAA and 14.29%,60.00% and 88.89% in SAA- Ⅰ respectively. It was much more effective with therapy of CSA and intensive immunosuppressive agents than with fundamental therapy. The response rate of intensive immunosuppressive agents in SAA and SAA- Ⅰ was even higher. Conclusions It is more effective with immunosuppressive agents on the base of CSA than with fundamental therapy in treating aplastic anemia in children. CSA combined with ALG/ATG, HDIVIG and HDMP can increase the response rate in SAA, especially SAA- Ⅰ patients.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 212-214 )