The study of two kinds of doses of penicillamine in treating hepatolenticuar degeneration
Abstract：Objective To determine the best plan with penicillamine in treating the patients with hepatolenticular degeneration. Methods Use two kinds of doses of penicillamine to treat two groups of the patients with hepatolenticular degeneration,one group using small dose[5～10mg/(kg·d)] and the other moderate dose[11～16mg/(kg·d)]. Observe the patients'clinical features, determine the average amount of daily urine copper of every week(total 8 weeks)and then draw the curve of urine copper and side effects. Results (1) The effect of copper driving of the moderate dose was better than that of the small dose during the first six weeks of treatment(P＜0.01). (2) After six weeks, the effects of the two doses were relatively stable(P＞0.05). (3)The difference of the side effects between the two groups was not clear. Conclusion The study suggests that we had better use moderate dose to treat patients with hepatolenticular degeneration in acute stage( the first six weeks) and small dose after acute stage( after six weeks).
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 165-166 )