Relations between erythrocyte Ca2+ , Mg2+ levels and cell membrane ATPase activities in patients with hypertension in obese children
Abstract：Objective To explore the roles of the metabolic disorders of cellular ions in pathogenesis of hypertension in obese children. Methods Erythrocyte membrane ATPase activities,plasma and cellular Ca2 + , Mg2 + levels were measured in 125(37 non-obese normotensives,34 obese normotensives,21 hypertensives and 33 obese hypertensives)middle school students aged 12～16 years. Results Erythrocyte membrane Na+ -K+-ATPase and Ca2+ -ATPase activities were significantly lower in obese children with normotension than those in non-obese normotensive children,and they were also significantly lower in two groups of hypertensive children than those in obese children with normotension. Erythrocyte Ca2+ in normotensive obese and two group of hypertensive children was significantly higher than that in non-obese normotensive children, but there were no significant differences between the three groups. There were no significant differences found in erythrocyte Mg2+ , plasma Ca2+ and Mg2+ between normotensive obese and normotensive non-obese children, but significant decreases were found in both groups of hypertensive children. Conclusion Decreased Na +-K+-ATPase and Ca2+ -ATPase activities may play important roles in pathogenesis of hypertension in obese children.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 148-150 )